Correlation Between Immunohistochemical Expression of Epstein-Barr Virus Latent Membrane Protein-1 (LMP-1) and Clinical Stages of Sinonasal Carcinoma

Introduction: Sinonasal tumors are rarely found. The protected nature of the sinuses makes early detection growing in these areas difficult. Epstein-Barr virus is one most common viruses found humans; which expresses Latent Membrane Protein-1 (LMP-1) that can transform cell lines and alter phenotype due to its oncogenic potential. Objective: To investigate relationship between immunohistochemical expression from clinical stages sinonasal carcinoma. Methods: This cross-sectional study was carried out DR. Wahidin Sudirohusodo General Hospital anatomic pathology Hasanuddin University Hospital, Makassar, South Sulawesi, Indonesia, October 2016 March 2017. Histopathological samples biopsy specimen all subjects diagnosed with carcinoma Otorhinolaryngology-Head Neck Surgery outpatient clinic were taken examined for LMP-1 using staining. paraffin block patients. Result: There 33 males (67.3%) 16 females (32.7%) who participated this study. majority participants aged ≥50 years (25 people, 51.0%) worked as farmers (27 55.1%). A significant correlation (Spearman’s r = 0.355 p <0.001). Conclusion: Higher correlates higher stage patients <50 years.